LOW DIMENSIONALITY OF PHENOTYPIC SPACE AS AN EMERGENT PROPERTY OF COORDINATED TEAMS IN BIOLOGICAL REGULATORY NETWORKS

Low dimensionality of phenotypic space as an emergent property of coordinated teams in biological regulatory networks

Summary: Cell-fate g35 coupe fender decisions involve coordinated genome-wide expression changes, typically leading to a limited number of phenotypes.Although often modeled as simple toggle switches, these rather simplistic representations often disregard the complexity of regulatory networks governing these changes.Here, we unravel design principl

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Rotational ThromboElastometry-guided blood component administration versus standard of care in patients with Cirrhosis and coagulopathy undergoing Invasive ProcEdures (RECIPE): study protocol for a randomised controlled trial

Abstract Background Patients with cirrhosis often undergo invasive procedures both for management of complications of their advanced liver disease, including treatment for hepatocellular carcinoma, as well as underlying comorbidities.Despite a current understanding that most patients with cirrhosis are in a rebalanced haemostatic state (despite abn

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